Common oxytocin receptor gene variant interacts with rejection sensitivity to influence cortisol reactivity during negative evaluation

Gene Variant

Background:

The study tested the hypothesis that variation in the oxytocin receptor gene (OXTR rs53576) and self-report of rejection sensitivity are associated with adrenocortical reactivity to social stress. Our findings suggest a curvilinear relationship between social rejection sensitivity and cortisol reactivity in the context of social rejection, warranting further consideration in future studies.