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Salivary Cortisol, Alpha-Amylase & Stress-Induced Telomere Shortening as Biomarkers of Health and Aging

April 21, 2016 by IISBR

Background: Recent research links life stress to premature telomere shortening and human aging. However, this association has only been demonstrated in Western contexts, where stress is typically lower and life expectancies longer. Using innovative approaches, this research strategy combined physical stress measures via the salivary analytes cortisol and α-amylase with self-assessments of psychosomatic stress, ethnographic observations, and telomere length assessment [telomere–fluorescence in situ hybridization (TEL-FISH) coupled with 3D imaging of buccal cell nuclei], providing high-resolution data amenable to multilevel statistical analysis. This research strengthens the case for stress-induced telomere shortening as a pancultural biomarker of compromised health and aging.

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UCI School of Social Ecology
Social Ecology I
Irvine, CA 92697-7050
www.uci.edu
www.socialecology.uci.edu

UCI Program in Public Health
UCI Health Sciences Complex
856 Health Sciences Quad
Irvine, CA 92697-3957
www.uci.edu www.publichealth.uci.edu

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